Studies on the Solvent Effect of DMSO on the medicinal potential of Hexanoate Ester
Studies on the Solvent Effect of DMSO on the medicinal potential of Hexanoate Ester
Kiranmayee1,R. T. Singh2
1 Senior Research Scholar, Dept. of Chemistry, V.K.S.University, Ara
2University Professor and former Dean of the Faculty of Science, V.K.S.University, Ara.
In order to highlight the biochemical and medicinal importance of hexanoate esters, the kinetics of alkali catalysedsolvolysis of Propyl Hexanoate Ester, having longer carbon chain was studied in water-DMSO media of varying composition ranging from 30 to 80% of DMSO in the reaction media at different temperatures varying from 20 to 40°C. The rate of the reaction was found to decrease with increasing proportion of the DMSO at all the temperatures. For variation in rate and activation energy of the reaction, it is inferred that effect of change in dielectric constant values and selective solvation of reactants are responsible for depletion in rate while solvation and desolvation of the transition and the initial states respectively are the causes for depletion in the values of iso-composition activation energy of tiles reaction.
From the increasing number of water molecules from 0.364 to 1.748 with increasing temperature of the reaction it is inferred that DMSO changes its mechanistic path from bimolecular to unimolecular.
ABSTRACT From the evaluated value of iso-kinetic temperature (283.46) of the reaction, it is concluded that in this reaction media (water-DMSO), there is a weak but appreciably considerable solvent-solute interaction.